InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dab1

Summary

InnateDB Protein

IDBP-267954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dab1

Protein Name

disabled homolog 1 (Drosophila)

Synonyms

AI956902; C630028C02Rik; scm; scr; scrambler; yot;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102440

InnateDB Gene

IDBG-169389 (Dab1)

Protein Structure

UniProt Annotation

Function

Adapter molecule functioning in neural development. May regulate SIAH1 activity. {ECO:0000269PubMed:9009273}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed mainly in brain. {ECO:0000269PubMed:9009273}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0042169	SH2 domain binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0001764	neuron migration
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0007494	midgut development
GO:0007628	adult walking behavior
GO:0016358	dendrite development
GO:0021517	ventral spinal cord development
GO:0021589	cerebellum structural organization
GO:0021795	cerebral cortex cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021813	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
GO:0021942	radial glia guided migration of Purkinje cell
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048712	negative regulation of astrocyte differentiation
GO:0050771	negative regulation of axonogenesis
GO:0051645	Golgi localization
GO:0097477	lateral motor column neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005903	brush border
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm