Homo sapiens Protein: RPSA
InnateDB Protein IDBP-26809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPSA
Protein Name ribosomal protein SA
Synonyms 37LRP; 67LR; E2; E2-1; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; RNE2; RNU108; SA;
Species Homo sapiens
Ensembl Protein ENSP00000346067
InnateDB Gene IDBG-26807 (RPSA)
Protein Structure
UniProt Annotation
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255HAMAP-Rule:MF_03016, ECO:0000269PubMed:15516338, ECO:0000269PubMed:16263087, ECO:0000269PubMed:6300843}.
Subcellular Localization Cell membrane. Cytoplasm. Nucleus {ECO:0000255HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255HAMAP-Rule:MF_03016}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
Experimentally validated
Total 165 [view]
Protein-Protein 165 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0043236 laminin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006407 rRNA export from nucleus
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0007155 cell adhesion
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR001865 Ribosomal protein S2
IPR005707 Ribosomal protein S2, eukaryotic/archaeal
IPR023591 Ribosomal protein S2, flavodoxin-like domain
PFAM PF00318
Post-translational Modifications
SwissProt P08865
PhosphoSite PhosphoSite-P08865
UniProt Splice Variant
Entrez Gene 6044
UniGene Hs.731290
RefSeq NP_002286
OMIM 180646
HPRD 01038
EMBL AB007146 AC099332 AF503367 BC005391 BC008867 BC010418 BC013827 BC034537 BC050688 BC053370 BC062714 BC066941 BC068062 BC070263 BC071693 BC071968 BC071969 BC071970 BC073863 BC107567 BT007219 CH471055 J03799 M14199 S37431 U36484 U43901 X15005 X61156
GenPept AAA36161 AAA36165 AAB22299 AAC50313 AAC50652 AAH05391 AAH08867 AAH10418 AAH13827 AAH34537 AAH50688 AAH53370 AAH62714 AAH66941 AAH68062 AAH70263 AAH71693 AAH71968 AAH71969 AAH71970 AAH73863 AAI07568 AAM33304 AAP35883 BAA25812 CAA33112 CAA43469 EAW64582 EAW64583 EAW64584 EAW64586