InnateDB Protein
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IDBP-26809.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPSA
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Protein Name
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ribosomal protein SA
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Synonyms
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37LRP; 67LR; E2; E2-1; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; RNE2; RNU108; SA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000346067
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InnateDB Gene
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IDBG-26807 (RPSA)
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Protein Structure
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Function |
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. {ECO:0000255HAMAP-Rule:MF_03016, ECO:0000269PubMed:15516338, ECO:0000269PubMed:16263087, ECO:0000269PubMed:6300843}.
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Subcellular Localization |
Cell membrane. Cytoplasm. Nucleus {ECO:0000255HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255HAMAP-Rule:MF_03016}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
165
[view]
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Protein-Protein |
165
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001865
Ribosomal protein S2
IPR005707
Ribosomal protein S2, eukaryotic/archaeal
IPR023591
Ribosomal protein S2, flavodoxin-like domain
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PFAM |
PF00318
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PRINTS |
PR00395
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P08865
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PhosphoSite |
PhosphoSite-P08865
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TrEMBL |
C9J9K3
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UniProt Splice Variant |
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Entrez Gene |
6044
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UniGene |
Hs.731290
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RefSeq |
NP_002286
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HUGO |
HGNC:6502
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OMIM |
180646
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CCDS |
CCDS2686
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HPRD |
01038
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IMGT |
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EMBL |
AB007146
AC099332
AF503367
BC005391
BC008867
BC010418
BC013827
BC034537
BC050688
BC053370
BC062714
BC066941
BC068062
BC070263
BC071693
BC071968
BC071969
BC071970
BC073863
BC107567
BT007219
CH471055
J03799
M14199
S37431
U36484
U43901
X15005
X61156
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GenPept |
AAA36161
AAA36165
AAB22299
AAC50313
AAC50652
AAH05391
AAH08867
AAH10418
AAH13827
AAH34537
AAH50688
AAH53370
AAH62714
AAH66941
AAH68062
AAH70263
AAH71693
AAH71968
AAH71969
AAH71970
AAH73863
AAI07568
AAM33304
AAP35883
BAA25812
CAA33112
CAA43469
EAW64582
EAW64583
EAW64584
EAW64586
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