InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPSA

Summary

InnateDB Gene

IDBG-26807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPSA

Gene Name

ribosomal protein SA

Synonyms

37LRP; 67LR; E2; E2-1; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; RNE2; RNU108; SA

Species

Homo sapiens

Ensembl Gene

ENSG00000168028

Encoded Proteins

IDBP-26809

ribosomal protein SA

IDBP-372870

ribosomal protein SA

IDBP-372871

ribosomal protein SA

IDBP-372876

ribosomal protein SA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:39406689-39412542

Strand

Forward strand

Band

p22.1

Transcripts

ENST00000301821	ENSP00000346067
ENST00000458478	ENSP00000410848
ENST00000443003	ENSP00000389351
ENST00000444512	ENSP00000396716
ENST00000477325
ENST00000475346
ENST00000487876
ENST00000490490
ENST00000478027
ENST00000495394

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.

Experimentally validated
Total	165 [view]
Protein-Protein	165 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005055	laminin receptor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006407	rRNA export from nucleus
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007155	cell adhesion
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030686	90S preribosome
GO:0070062	extracellular vesicular exosome