InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grb2

Summary

InnateDB Protein

IDBP-268647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grb2

Protein Name

growth factor receptor bound protein 2

Synonyms

AA408164; Ash;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102108

InnateDB Gene

IDBG-214339 (Grb2)

Protein Structure

UniProt Annotation

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus {ECO:0000269PubMed:11571277}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 605 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	120 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	605 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0043560	insulin receptor substrate binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007265	Ras protein signal transduction
GO:0007568	aging
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0030154	cell differentiation
GO:0030838	positive regulation of actin filament polymerization
GO:0031623	receptor internalization
GO:0042770	signal transduction in response to DNA damage
GO:0043408	regulation of MAPK cascade
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0051291	protein heterooligomerization
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0071479	cellular response to ionizing radiation
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0070436	Grb2-EGFR complex

Protein Structure and Domains

PDB ID

MGI:95805

InterPro

IPR001452 SH3 domain
IPR003646 SH3-like domain, bacterial-type
IPR011511 Variant SH3 domain

PFAM

PF00018
PF14604
PF08239
PF08460
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00287

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60631

PhosphoSite

PhosphoSite-Q60631

TrEMBL

UniProt Splice Variant

Entrez Gene

14784

UniGene

Mm.472452

RefSeq

MGI ID

4GBQ

MGI Symbol

Grb2

OMIM

CCDS

HPRD

IMGT

EMBL

BC052377 BC085254 D85748 U07617

GenPept

AAB40022 AAH52377 AAH85254 BAA12862