Version 5.4
Mus musculus Protein: Grb2
Summary
InnateDB Protein IDBP-268651.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Grb2
Protein Name growth factor receptor bound protein 2
Synonyms AA408164; Ash;
Species Mus musculus
Ensembl Protein ENSMUSP00000102104
InnateDB Gene IDBG-214339 (Grb2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 605 interaction(s) predicted by orthology.
Experimentally validated
Total 120 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 605 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0043560 insulin receptor substrate binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0030154 cell differentiation
GO:0030838 positive regulation of actin filament polymerization
GO:0031623 receptor internalization
GO:0042770 signal transduction in response to DNA damage
GO:0043408 regulation of MAPK cascade
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0051291 protein heterooligomerization
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0071479 cellular response to ionizing radiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0070436 Grb2-EGFR complex
Protein Structure and Domains
PDB ID MGI:95805
InterPro IPR000980 SH2 domain
IPR001452 SH3 domain
IPR003646 SH3-like domain, bacterial-type
IPR011511 Variant SH3 domain
PFAM PF00017
PF14633
PF00018
PF14604
PF08239
PF08460
PF07653
PRINTS PR00401
PR00452
PIRSF
SMART SM00252
SM00326
SM00287
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B1AT95
UniProt Splice Variant
Entrez Gene 14784
UniGene Mm.472452
RefSeq
MGI ID
MGI Symbol Grb2
OMIM
CCDS
HPRD
IMGT
EMBL AL645852 AL732491
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca