InnateDB Protein
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IDBP-268993.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppih
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Protein Name
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peptidyl prolyl isomerase H
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Synonyms
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1100001J08Rik; 2010111B15Rik; 4833408F11Rik; AI464484; CYP-20; CYPH; D4Wsu43e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101925
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InnateDB Gene
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IDBG-182988 (Ppih)
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Protein Structure
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Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003755
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peptidyl-prolyl cis-trans isomerase activity
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GO:0043021
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ribonucleoprotein complex binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106499
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InterPro |
IPR002130
Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR029000
Cyclophilin-like domain
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PFAM |
PF00160
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PRINTS |
PR00153
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D868
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PhosphoSite |
PhosphoSite-Q9D868
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TrEMBL |
Q4G0C5
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UniProt Splice Variant |
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Entrez Gene |
66101
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UniGene |
Mm.489485
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RefSeq |
NP_082953
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MGI ID |
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MGI Symbol |
Ppih
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OMIM |
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CCDS |
CCDS18580
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HPRD |
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IMGT |
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EMBL |
AK003179
AK005202
AK008394
AK014665
AK164299
BC016565
BC050116
BC098490
BX470216
CH466524
CH466552
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GenPept |
AAH50116
AAH98490
BAB22623
BAB23880
BAB25645
BAB29493
BAE37724
EDL30449
EDL30451
EDL37598
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