InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppih

Summary

InnateDB Protein

IDBP-268995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppih

Protein Name

peptidyl prolyl isomerase H

Synonyms

1100001J08Rik; 2010111B15Rik; 4833408F11Rik; AI464484; CYP-20; CYPH; D4Wsu43e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101924

InnateDB Gene

IDBG-182988 (Ppih)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0008380	RNA splicing
GO:0045070	positive regulation of viral genome replication