InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgam

Summary

InnateDB Protein

IDBP-269167.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Itgam

Protein Name

integrin alpha M

Synonyms

Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101849

InnateDB Gene

IDBG-210531 (Itgam)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0014005	microglia development
GO:0016337	single organismal cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0050798	activated T cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96607

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF00092
PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt