Mus musculus Gene: Itgam
Summary
InnateDB Gene IDBG-210531.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgam
Gene Name integrin alpha M
Synonyms Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1;
Species Mus musculus
Ensembl Gene ENSMUSG00000030786
Encoded Proteins
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
integrin alpha M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.
Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
[Homo sapiens] ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169896:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128062640-128128160
Strand Forward strand
Band F3
Transcripts
ENSMUST00000098015 ENSMUSP00000095625
ENSMUST00000064821 ENSMUSP00000068468
ENSMUST00000106242 ENSMUSP00000101849
ENSMUST00000106240 ENSMUSP00000101847
ENSMUST00000120355 ENSMUSP00000113957
ENSMUST00000119696 ENSMUSP00000113412
ENSMUST00000156593 ENSMUSP00000121676
ENSMUST00000126475 ENSMUSP00000117293
ENSMUST00000134694 ENSMUSP00000117120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001846 opsonin binding
GO:0001948 glycoprotein binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002523 leukocyte migration involved in inflammatory response
GO:0006412 translation
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0014005 microglia development
GO:0016337 single organismal cell-cell adhesion
GO:0030593 neutrophil chemotaxis
GO:0045087 innate immune response (InnateDB)
GO:0045123 cellular extravasation
GO:0050798 activated T cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005840 ribosome
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Extracellular matrix organization pathway
Toll-Like Receptors Cascades pathway
Integrin cell surface interactions pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Integrin cell surface interactions pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 16409
UniGene Mm.262106 Mm.472418
RefSeq NM_001082960 NM_008401
OMIM
CCDS CCDS21889 CCDS40149
HPRD
IMGT
MGI ID MGI:96607
MGI Symbol Itgam
EMBL
GenPept
RNA Seq Atlas 16409