InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgam

Summary

InnateDB Protein

IDBP-269169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgam

Protein Name

integrin alpha M

Synonyms

Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101847

InnateDB Gene

IDBG-210531 (Itgam)

Protein Structure

UniProt Annotation

Function

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Predominantly expressed in monocytes and granulocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046872	metal ion binding

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0014005	microglia development
GO:0016337	single organismal cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0050798	activated T cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96607

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF00092
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05555

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

16409

UniGene

Mm.472418

RefSeq

MGI ID

MGI Symbol

Itgam

OMIM

CCDS

HPRD

IMGT

EMBL

AK039444 M14293 X07640

GenPept

AAA39484 BAC30350 CAA30479