InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICAM5

Summary

InnateDB Protein

IDBP-26926.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICAM5

Protein Name

intercellular adhesion molecule 5, telencephalin

Synonyms

TLCN; TLN;

Species

Homo sapiens

Ensembl Protein

ENSP00000221980

InnateDB Gene

IDBG-26924 (ICAM5)

Protein Structure

UniProt Annotation

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006909	phagocytosis
GO:0016337	single organismal cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003988 Intercellular adhesion molecule
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013768 Intercellular adhesion molecule, N-terminal

PFAM

PF07679
PF03921

PRINTS

PR01472
PR01473

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt