Version 5.4
Homo sapiens Gene: ICAM5
Summary
InnateDB Gene IDBG-26924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM5
Gene Name intercellular adhesion molecule 5, telencephalin
Synonyms TLCN; TLN
Species Homo sapiens
Ensembl Gene ENSG00000105376
Encoded Proteins
IDBP-26926
intercellular adhesion molecule 5, telencephalin
IDBP-765806
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10289981-10296778
Strand Forward strand
Band p13.2
Transcripts
ENST00000221980 ENSP00000221980
ENST00000586480
ENST00000588912
ENST00000586004
ENST00000587398 ENSP00000464796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006909 phagocytosis
GO:0016337 single organismal cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032174
View Gene Order
ENSBTAG00000010316
Not yet available
Cross-References
SwissProt
TrEMBL K7EIL3
UniProt Splice Variant
Entrez Gene 7087
UniGene Hs.465862
RefSeq NM_003259
HUGO HGNC:5348
OMIM 601852
CCDS CCDS12233
HPRD 03509
IMGT
EMBL AC011511
GenPept
RNA Seq Atlas 7087

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca