InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX16

Summary

InnateDB Protein

IDBP-26929.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX16

Protein Name

sorting nexin 16

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322652

InnateDB Gene

IDBG-26927 (SNX16)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. {ECO:0000269PubMed:12813048, ECO:0000269PubMed:15951806}.

Subcellular Localization

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in placenta, lung, liver,heart and pancreas. {ECO:0000269PubMed:12813048}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0008333	endosome to lysosome transport
GO:0045022	early endosome to late endosome transport

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0031313	extrinsic component of endosome membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane