Mus musculus Protein: Slc22a18 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-269857.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Slc22a18 | ||||||||||||
Protein Name | solute carrier family 22 (organic cation transporter), member 18 | ||||||||||||
Synonyms | AW260131; BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2; p45-BWR1A; Slc22a1l; TSSC5; | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000101537 | ||||||||||||
InnateDB Gene | IDBG-212738 (Slc22a18) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis. {ECO:0000269PubMed:9499412, ECO:0000269PubMed:9570947, ECO:0000269PubMed:9802569}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:1336884 | ||||||||||||
InterPro |
IPR001958
Tetracycline resistance protein, TetA/multidrug resistance protein MdtG IPR010290 Transmembrane secretion effector IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF05977
PF07690 |
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PRINTS |
PR01035
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PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q78KK3 | ||||||||||||
PhosphoSite | PhosphoSite-Q78KK3 | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 18400 | ||||||||||||
UniGene | Mm.271740 | ||||||||||||
RefSeq | NP_001036225 | ||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Slc22a18 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS22041 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AB012084 AF028739 AF037065 AJ276505 BC003734 | ||||||||||||
GenPept | AAB82728 AAC04788 AAH03734 BAA32780 CAC16401 | ||||||||||||