InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk11b

Summary

InnateDB Protein

IDBP-270530.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk11b

Protein Name

cyclin-dependent kinase 11B

Synonyms

AA989746; Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110; CDK11-p46; CDK11-p58; p58;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101225

InnateDB Gene

IDBG-207702 (Cdk11b)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the normal cell cycle progression. In vitro, this protein kinase has been shown to phosphorylate a number of substrates, including histone h1, casein, and galactosyltransferase. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001824	blastocyst development
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007088	regulation of mitosis
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:88353

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt