InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grik2

Summary

InnateDB Protein

IDBP-270783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grik2

Protein Name

glutamate receptor, ionotropic, kainate 2 (beta 2)

Synonyms

AW124492; GluK2; Glur-6; Glur6; Glurbeta2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101125

InnateDB Gene

IDBG-149430 (Grik2)

Protein Structure

UniProt Annotation

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. {ECO:0000269PubMed:19217376}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant in the cerebellum and the hypothalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006874	cellular calcium ion homeostasis
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043524	negative regulation of neuron apoptotic process
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050806	positive regulation of synaptic transmission
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95815

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt