Version 5.4
Mus musculus Protein: Grik2
Summary
InnateDB Protein IDBP-270787.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Grik2
Protein Name glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms AW124492; GluK2; Glur-6; Glur6; Glurbeta2;
Species Mus musculus
Ensembl Protein ENSMUSP00000101123
InnateDB Gene IDBG-149430 (Grik2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0015277 kainate selective glutamate receptor activity
Biological Process
GO:0001662 behavioral fear response
GO:0006874 cellular calcium ion homeostasis
GO:0006886 intracellular protein transport
GO:0007268 synaptic transmission
GO:0019228 neuronal action potential
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043524 negative regulation of neuron apoptotic process
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060080 regulation of inhibitory postsynaptic membrane potential
Cellular Component
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030425 dendrite
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:95815
InterPro IPR001828 Extracellular ligand-binding receptor
IPR028082 Periplasmic binding protein-like I
PFAM PF01094
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q6PAQ0
UniProt Splice Variant
Entrez Gene 14806
UniGene Mm.488490
RefSeq
MGI ID
MGI Symbol Grik2
OMIM
CCDS
HPRD
IMGT
EMBL AC110043 AC113305 AC115891 AC152981 AC153801 AC153953 AK141539 BC060154
GenPept AAH60154 BAE24724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca