Version 5.4
Mus musculus Protein: Mbd3
Summary
InnateDB Protein IDBP-271065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mbd3
Protein Name methyl-CpG binding domain protein 3
Synonyms AI181826; AU019209;
Species Mus musculus
Ensembl Protein ENSMUSP00000100986
InnateDB Gene IDBG-174078 (Mbd3)
Protein Structure
UniProt Annotation
Function Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000250, ECO:0000269PubMed:9774669}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14610093, ECO:0000269PubMed:9774669}. Chromosome {ECO:0000250}. Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in brain, heart, kidney, liver, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. {ECO:0000269PubMed:9774669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006346 methylation-dependent chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0009888 tissue development
GO:0016573 histone acetylation
Cellular Component
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016581 NuRD complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:1333812
InterPro IPR001739 Methyl-CpG DNA binding
IPR016177 DNA-binding domain
PFAM PF01429
PRINTS
PIRSF
SMART SM00391
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2D8
PhosphoSite PhosphoSite-Q9Z2D8
TrEMBL
UniProt Splice Variant
Entrez Gene 17192
UniGene Mm.7142
RefSeq XP_006513367
MGI ID
MGI Symbol Mbd3
OMIM
CCDS
HPRD
IMGT
EMBL AF072248 AF120995 BC038264
GenPept AAC68877 AAD48909 AAH38264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca