Mus musculus Gene: Mbd3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-174078.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mbd3 | ||||||||||||||||||||||
Gene Name | methyl-CpG binding domain protein 3 | ||||||||||||||||||||||
Synonyms | AI181826; AU019209 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000035478 | ||||||||||||||||||||||
Encoded Proteins |
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071655:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:80392539-80399550 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
HDACs deacetylate histones pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Transcription Initiation pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Clearance pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Signaling events mediated by HDAC Class I
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Cross-References | |||||||||||||||||||||||
SwissProt | Q9Z2D8 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 17192 | ||||||||||||||||||||||
UniGene | Mm.7142 | ||||||||||||||||||||||
RefSeq | NM_013595 XM_006513302 XM_006513303 XM_006513304 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS24020 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1333812 | ||||||||||||||||||||||
MGI Symbol | Mbd3 | ||||||||||||||||||||||
EMBL | AF072248 AF120995 BC038264 | ||||||||||||||||||||||
GenPept | AAC68877 AAD48909 AAH38264 | ||||||||||||||||||||||
RNA Seq Atlas | 17192 | ||||||||||||||||||||||