InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dot1l

Summary

InnateDB Protein

IDBP-271092.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Dot1l

Protein Name

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100973

InnateDB Gene

IDBG-175749 (Dot1l)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity

Biological Process

GO:0034968	histone lysine methylation
GO:0046425	regulation of JAK-STAT cascade
GO:2000677	regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:2143886

InterPro

IPR013110 Histone methylation DOT1
IPR021169 Histone H3-K79 methyltransferase, metazoa
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08123

PRINTS

PIRSF

PIRSF037123

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite