Version 5.4
Mus musculus Gene: Dot1l
Summary
InnateDB Gene IDBG-175749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dot1l
Gene Name DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000061589
Encoded Proteins
IDBP-271092
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-622912
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-536968
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-622916
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-542750
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104885:
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80755206-80795461
Strand Forward strand
Band C1
Transcripts
ENSMUST00000105336 ENSMUSP00000100973
ENSMUST00000127740 ENSMUSP00000130408
ENSMUST00000147579
ENSMUST00000150338 ENSMUSP00000116581
ENSMUST00000149394 ENSMUSP00000127762
ENSMUST00000138505 ENSMUSP00000119492
ENSMUST00000163526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
Biological Process
GO:0016571 histone methylation
GO:0034968 histone lysine methylation
GO:0046425 regulation of JAK-STAT cascade
GO:2000677 regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104885
View Gene Order
ENSBTAG00000009996
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F7CVL0 Q5YL88
UniProt Splice Variant
Entrez Gene 208266
UniGene Mm.393160
RefSeq NM_199322
OMIM
CCDS CCDS35985
HPRD
IMGT
MGI ID MGI:2143886
MGI Symbol Dot1l
EMBL AC166937 AY377920
GenPept AAQ82850
RNA Seq Atlas 208266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca