InnateDB Protein
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IDBP-271110.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pip5k1c
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Protein Name
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phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
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Synonyms
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AI115456; AI835305; Pip5kIgamma;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100964
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InnateDB Gene
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IDBG-177962 (Pip5k1c)
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Protein Structure
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Function |
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A have a role during embryogenesis and together with PIP5K1B may have a role immediately after birth. {ECO:0000269PubMed:12422220, ECO:0000269PubMed:15386003, ECO:0000269PubMed:16707488, ECO:0000269PubMed:17609388, ECO:0000269PubMed:17635937, ECO:0000269PubMed:17928408, ECO:0000269PubMed:19153220, ECO:0000269PubMed:20622009, ECO:0000269PubMed:20855869, ECO:0000269PubMed:9535851}.
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Subcellular Localization |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Note=During directional migration isoform 1 localized at the uropodium, and isoform 3 localized all along cell membrane including the uropodium and the leading edge.
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Disease Associations |
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Tissue Specificity |
High expression in brain. Also detected in lung, thymus, heart, testicle, kidney and embryo. Highly expressed in forebrain, in particular in cerebellum, hippocampus and cerebral cortex. {ECO:0000269PubMed:14741049, ECO:0000269PubMed:20622009, ECO:0000269PubMed:9535851}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1298224
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InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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PFAM |
PF01504
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PRINTS |
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PIRSF |
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SMART |
SM00330
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TIGRFAMs |
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Modification |
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SwissProt |
O70161
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PhosphoSite |
PhosphoSite-O70161
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18717
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UniGene |
Mm.471109
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RefSeq |
NP_032870
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MGI ID |
2H7E
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MGI Symbol |
Pip5k1c
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OMIM |
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CCDS |
CCDS35994
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HPRD |
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IMGT |
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EMBL |
AB006916
AK122319
AK154816
AK171576
BC019138
BC094665
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GenPept |
AAH19138
AAH94665
BAA25664
BAC65601
BAE32849
BAE42536
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