InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pip5k1c

Summary

InnateDB Gene

IDBG-177962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pip5k1c

Gene Name

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

Synonyms

AI115456; AI835305; Pip5kIgamma

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034902

Encoded Proteins

IDBP-177964

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-271110

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-532525

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-535855

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-539651

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-534198

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-533562

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

IDBP-535792

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186111:
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:81292963-81319973

Strand

Forward strand

Band

Transcripts

ENSMUST00000045469	ENSMUSP00000038225
ENSMUST00000105327	ENSMUSP00000100964
ENSMUST00000163075	ENSMUSP00000124155
ENSMUST00000160291	ENSMUSP00000125645
ENSMUST00000161854	ENSMUSP00000124004
ENSMUST00000161719	ENSMUSP00000125461
ENSMUST00000161869	ENSMUSP00000124235
ENSMUST00000161586	ENSMUSP00000124612
ENSMUST00000159895
ENSMUST00000159636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016307	phosphatidylinositol phosphate kinase activity
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:1990147	talin binding

Biological Process

GO:0006887	exocytosis
GO:0006909	phagocytosis
GO:0006935	chemotaxis
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007409	axonogenesis
GO:0046488	phosphatidylinositol metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0070527	platelet aggregation