InnateDB Protein
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IDBP-271208.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kitl
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Protein Name
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kit ligand
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Synonyms
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blz; Clo; Con; contrasted; Gb; Kitlg; Mgf; SCF; SF; Sl; SLF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100920
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InnateDB Gene
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IDBG-187862 (Kitl)
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Protein Structure
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Function |
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
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Subcellular Localization |
Isoform 1: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.Soluble KIT ligand: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0001755
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neural crest cell migration
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GO:0002763
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positive regulation of myeloid leukocyte differentiation
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GO:0007155
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cell adhesion
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GO:0007281
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germ cell development
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GO:0008284
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positive regulation of cell proliferation
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GO:0008584
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male gonad development
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GO:0033026
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negative regulation of mast cell apoptotic process
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GO:0035162
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embryonic hemopoiesis
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GO:0035234
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ectopic germ cell programmed cell death
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GO:0043066
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negative regulation of apoptotic process
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GO:0043406
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positive regulation of MAP kinase activity
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GO:0045087
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innate immune response (InnateDB)
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GO:0045636
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positive regulation of melanocyte differentiation
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GO:0045740
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positive regulation of DNA replication
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GO:0046579
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positive regulation of Ras protein signal transduction
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0070668
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positive regulation of mast cell proliferation
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GO:0097192
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extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
MGI:96974
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InterPro |
IPR003452
Stem cell factor
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF02404
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PRINTS |
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PIRSF |
PIRSF015599
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P20826
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17311
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UniGene |
Mm.456756
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RefSeq |
NP_038626
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MGI ID |
2O27
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MGI Symbol |
Kitl
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OMIM |
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CCDS |
CCDS36046
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HPRD |
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IMGT |
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EMBL |
AK018777
AK134301
AK165233
BC011322
M57647
M59912
M59915
S40364
S40534
U44724
U44725
X68989
X95381
X99322
Y10287
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GenPept |
AAA39538
AAA39539
AAA40095
AAB22554
AAB22555
AAC52447
AAH11322
BAB31402
BAE22091
BAE38091
CAA48778
CAA64667
CAA67698
CAA71329
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