Mus musculus Gene: Kitl
Summary
InnateDB Gene IDBG-187862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kitl
Gene Name kit ligand
Synonyms blz; Clo; Con; contrasted; Gb; Kitlg; Mgf; SCF; SF; Sl; SLF;
Species Mus musculus
Ensembl Gene ENSMUSG00000019966
Encoded Proteins
kit ligand
kit ligand
kit ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Kitl is a PI3K-activating ligand that increases the secretion of Il6 and Tnfa in LPS-stimulated mast cells, as well as the attenuating the production of Il1b.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] KITLG is a PI3K-activating ligand that increases the secretion of IL6 and TNFA in LPS-stimulated mast cells, as well as the attenuating the production of IL1B. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049130:
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100015630-100100413
Strand Forward strand
Band D1
Transcripts
ENSMUST00000020129 ENSMUSP00000020129
ENSMUST00000105283 ENSMUSP00000100920
ENSMUST00000130190 ENSMUSP00000123360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001755 neural crest cell migration
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0007155 cell adhesion
GO:0007281 germ cell development
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0033026 negative regulation of mast cell apoptotic process
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045636 positive regulation of melanocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0046579 positive regulation of Ras protein signal transduction
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668 positive regulation of mast cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Regulation of KIT signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
Melanogenesis pathway
Pathways in cancer pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
KitReceptor pathway
REACTOME
DAP12 interactions pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
Signaling by FGFR pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
Regulation of KIT signaling pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
Melanogenesis pathway
Pathways in cancer pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
PID NCI
C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.403211 Mm.45124 Mm.456756
RefSeq NM_013598 XM_006513314
OMIM
CCDS CCDS36046
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas