InnateDB Protein
|
IDBP-271223.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Syt1
|
Protein Name
|
synaptotagmin I
|
Synonyms
|
AW124717; G630098F17Rik; SytI;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000100912
|
InnateDB Gene
|
IDBG-189557 (Syt1)
|
Protein Structure
|
|
Function |
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
|
Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
13
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
28 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:99667
|
InterPro |
IPR000008
C2 domain
IPR001565
Synaptotagmin
|
PFAM |
PF00168
|
PRINTS |
PR00360
PR00399
|
PIRSF |
|
SMART |
SM00239
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P46096
|
PhosphoSite |
PhosphoSite-P46096
|
TrEMBL |
H6RXZ1
|
UniProt Splice Variant |
|
Entrez Gene |
20979
|
UniGene |
Mm.399963
|
RefSeq |
NP_001239270
|
MGI ID |
|
MGI Symbol |
Syt1
|
OMIM |
|
CCDS |
CCDS24163
|
HPRD |
|
IMGT |
|
EMBL |
AK078790
BC042519
CH466539
D37792
FR827897
|
GenPept |
AAH42519
BAA07040
BAC37395
CBZ98840
EDL21707
|
|
|