InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNGT1

Summary

InnateDB Protein

IDBP-27198.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNGT1

Protein Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Synonyms

GNG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000248572

InnateDB Gene

IDBG-27196 (GNGT1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Retinal rod outer segment.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0008104	protein localization
GO:0010659	cardiac muscle cell apoptotic process
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0042462	eye photoreceptor cell development
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0097381	photoreceptor disc membrane