InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rxrb

Summary

InnateDB Protein

IDBP-273696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rxrb

Protein Name

retinoid X receptor beta

Synonyms

AL023085; H-2RIIBP; Nr2b2; RCoR-1; Rub;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112311

InnateDB Gene

IDBG-169595 (Rxrb)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). Binds to both, class I regulatory element of major histocompatibility class I genes (CRE) and the estrogen response element (ERE).

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In all tissues tested including brain, thymus spleen and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004886	9-cis retinoic acid receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:98215

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR021780 Nuclear/hormone receptor activator site AF-1

PFAM

PF00104
PF00105
PF11825

PRINTS

PR00545
PR00047
PR00398
PR01282
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt