InnateDB Protein
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IDBP-274197.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hdac7
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Protein Name
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histone deacetylase 7
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Synonyms
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5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112110
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InnateDB Gene
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IDBG-179042 (Hdac7)
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Protein Structure
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Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. {ECO:0000269PubMed:10640276}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart and lung. Expressed at intermediate level in muscle. {ECO:0000269PubMed:10640276, ECO:0000269PubMed:11279209}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
109 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1891835
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InterPro |
IPR000286
Histone deacetylase superfamily
IPR017320
Histone deacetylase class II, eukaryotic
IPR023801
Histone deacetylase domain
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PFAM |
PF00850
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PRINTS |
PR01270
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PIRSF |
PIRSF037911
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C2B3
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PhosphoSite |
PhosphoSite-Q8C2B3
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TrEMBL |
Q1EDY4
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UniProt Splice Variant |
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Entrez Gene |
56233
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UniGene |
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RefSeq |
NP_001191204
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MGI ID |
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MGI Symbol |
Hdac7
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OMIM |
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CCDS |
CCDS57006
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HPRD |
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IMGT |
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EMBL |
AF207749
AK030863
AK036586
AK044287
AK088828
AK088945
AY943911
AY943913
BC057332
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GenPept |
AAF31419
AAH57332
AAY22407
AAY22409
BAC27161
BAC29493
BAC31856
BAC40598
BAC40666
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