InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctss

Summary

InnateDB Protein

IDBP-274449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctss

Protein Name

cathepsin S

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112006

InnateDB Gene

IDBG-172850 (Ctss)

Protein Structure

UniProt Annotation

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Widely expressed with highest expression found in non-skeletal tissues. Relatively high levels found in skeletal tissues. {ECO:0000269PubMed:10395917}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0034769	basement membrane disassembly
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process