InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hk1

Summary

InnateDB Protein

IDBP-274612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hk1

Protein Name

hexokinase 1

Synonyms

BB404130; dea; Hk-1; Hk1-s; mHk1-s;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111946

InnateDB Gene

IDBG-157046 (Hk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Isoform HK1: Mitochondrion outer membrane; Peripheral membrane protein.Isoform HK1-SC: Membrane. Note=Isoform HK1- SC is an integral membrane protein.

Disease Associations

Tissue Specificity

In rapidly growing tumor cells exhibiting high glucose catabolic rates, isoform HK1 is markedly elevated. Isoform HK1-SA, isoform HK1-SB and isoform HK1-SC are found only in spermatogenic cells. Isoform HK1-SC is detected in round spermatids, condensing spermatids and mature sperm where it is found in the head membranes, mitochondria of the midpiece and the fibrous sheath of the flagellum. Expressed within the principal piece and midpiece of sperm tail (at protein level). {ECO:0000269PubMed:23055941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0061621	canonical glycolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0005929	cilium
GO:0045121	membrane raft
GO:0097228	sperm principal piece