InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CARTPT

Summary

InnateDB Protein

IDBP-27494.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CARTPT

Protein Name

CART prepropeptide

Synonyms

CART;

Species

Homo sapiens

Ensembl Protein

ENSP00000296777

InnateDB Gene

IDBG-27492 (CARTPT)

Protein Structure

UniProt Annotation

Function

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. {ECO:0000269PubMed:9590691}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001678	cellular glucose homeostasis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0008343	adult feeding behavior
GO:0009267	cellular response to starvation
GO:0032099	negative regulation of appetite
GO:0032812	positive regulation of epinephrine secretion
GO:0032922	circadian regulation of gene expression
GO:0045671	negative regulation of osteoclast differentiation
GO:0045777	positive regulation of blood pressure
GO:0045779	negative regulation of bone resorption
GO:0046850	regulation of bone remodeling
GO:0050796	regulation of insulin secretion
GO:0051971	positive regulation of transmission of nerve impulse
GO:0070093	negative regulation of glucagon secretion
GO:0070253	somatostatin secretion