Homo sapiens Gene: CARTPT
Summary
InnateDB Gene IDBG-27492.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARTPT
Gene Name CART prepropeptide
Synonyms CART;
Species Homo sapiens
Ensembl Gene ENSG00000164326
Encoded Proteins
CART prepropeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:71719163-71721048
Strand Forward strand
Band q13.2
Transcripts
ENST00000296777 ENSP00000296777
ENST00000513096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001678 cellular glucose homeostasis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0008343 adult feeding behavior
GO:0009267 cellular response to starvation
GO:0032099 negative regulation of appetite
GO:0032812 positive regulation of epinephrine secretion
GO:0032922 circadian regulation of gene expression
GO:0045671 negative regulation of osteoclast differentiation
GO:0045777 positive regulation of blood pressure
GO:0045779 negative regulation of bone resorption
GO:0046850 regulation of bone remodeling
GO:0050796 regulation of insulin secretion
GO:0051971 positive regulation of transmission of nerve impulse
GO:0070093 negative regulation of glucagon secretion
GO:0070253 somatostatin secretion
Cellular Component
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q16568
TrEMBL
UniProt Splice Variant
Entrez Gene 9607
UniGene Hs.1707
RefSeq NM_004291
HUGO HGNC:24323
OMIM 602606
CCDS CCDS4011
HPRD 04006
IMGT
EMBL BC029882 CH471084 CR542216 U16826 U20325
GenPept AAB08010 AAB08011 AAH29882 CAG47012 EAW95694
RNA Seq Atlas 9607