Version 5.4
Homo sapiens Gene: CARTPT
Summary
InnateDB Gene IDBG-27492.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARTPT
Gene Name CART prepropeptide
Synonyms CART
Species Homo sapiens
Ensembl Gene ENSG00000164326
Encoded Proteins
IDBP-27494
CART prepropeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:71719163-71721048
Strand Forward strand
Band q13.2
Transcripts
ENST00000296777 ENSP00000296777
ENST00000513096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001678 cellular glucose homeostasis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0008343 adult feeding behavior
GO:0009267 cellular response to starvation
GO:0032099 negative regulation of appetite
GO:0032812 positive regulation of epinephrine secretion
GO:0032922 circadian regulation of gene expression
GO:0045671 negative regulation of osteoclast differentiation
GO:0045777 positive regulation of blood pressure
GO:0045779 negative regulation of bone resorption
GO:0046850 regulation of bone remodeling
GO:0050796 regulation of insulin secretion
GO:0051971 positive regulation of transmission of nerve impulse
GO:0070093 negative regulation of glucagon secretion
GO:0070253 somatostatin secretion
Cellular Component
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021647
View Gene Order
ENSBTAG00000047486
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1707
RefSeq NM_004291
HUGO
OMIM
CCDS CCDS4011
HPRD 04006
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca