InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WWP1

Summary

InnateDB Protein

IDBP-27570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWP1

Protein Name

WW domain containing E3 ubiquitin protein ligase 1

Synonyms

AIP5; hSDRP1; Tiul1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265428

InnateDB Gene

IDBG-27568 (WWP1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. {ECO:0000269PubMed:12535537, ECO:0000269PubMed:15221015, ECO:0000269PubMed:15359284}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269PubMed:11779188, ECO:0000269PubMed:9647693}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0016567	protein ubiquitination
GO:0034220	ion transmembrane transport
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046718	viral entry into host cell
GO:0055085	transmembrane transport