Version 5.4
Homo sapiens Protein: GGT5
Summary
InnateDB Protein IDBP-2787.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT5
Protein Name gamma-glutamyltransferase 5
Synonyms GGT-REL; GGTLA1;
Species Homo sapiens
Ensembl Protein ENSP00000263112
InnateDB Gene IDBG-2783 (GGT5)
Protein Structure
UniProt Annotation
Function Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031362 anchored component of external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000101 Gamma-glutamyltranspeptidase
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF01019
PRINTS PR01210
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P36269
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 2687
UniGene Hs.437156
RefSeq NP_001093252
HUGO HGNC:4260
OMIM 137168
CCDS CCDS42989
HPRD 00666
IMGT
EMBL AK292006 AL117414 AP000353 AP000354 BC011362 BC073999 BT009808 CH471095 CT841518 M64099
GenPept AAA58503 AAH11362 AAH73999 AAP88810 BAF84695 CAB55910 CAJ86448 EAW59643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca