Homo sapiens Gene: GGT5
Summary
InnateDB Gene IDBG-2783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT5
Gene Name gamma-glutamyltransferase 5
Synonyms GGT-REL; GGTLA1;
Species Homo sapiens
Ensembl Gene ENSG00000099998
Encoded Proteins
gamma-glutamyltransferase 5
gamma-glutamyltransferase 5
gamma-glutamyltransferase 5
gamma-glutamyltransferase 5
gamma-glutamyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene is a member of a gene family that encodes gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn\'t convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24219654-24245142
Strand Reverse strand
Band q11.23
Transcripts
ENST00000327365 ENSP00000330080
ENST00000263112 ENSP00000263112
ENST00000398292 ENSP00000381340
ENST00000425408 ENSP00000402917
ENST00000424217 ENSP00000412964
ENST00000623756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006520 cellular amino acid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006954 inflammatory response
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031362 anchored component of external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Glutathione synthesis and recycling pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Taurine and hypotaurine metabolism pathway
Cyanoamino acid metabolism pathway
Glutathione metabolism pathway
Arachidonic acid metabolism pathway
INOH
Prostaglandin Leukotriene metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001099781 NM_001099782 NM_004121
HUGO
OMIM
CCDS CCDS13825 CCDS42989 CCDS42990
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas