InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGAM

Summary

InnateDB Protein

IDBP-28141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAM

Protein Name

integrin, alpha M (complement component 3 receptor 3 subunit)

Synonyms

CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6;

Species

Homo sapiens

Ensembl Protein

ENSP00000287497

InnateDB Gene

IDBG-28139 (ITGAM)

Protein Structure

UniProt Annotation

Function

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Systemic lupus erythematosus 6 (SLEB6) [MIM:609939]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Predominantly expressed in monocytes and granulocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	21 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0030198	extracellular matrix organization
GO:0034142	toll-like receptor 4 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF00092
PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt