InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGAM

Summary

InnateDB Gene

IDBG-28139.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAM

Gene Name

integrin, alpha M (complement component 3 receptor 3 subunit)

Synonyms

CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6;

Species

Homo sapiens

Ensembl Gene

ENSG00000169896

Encoded Proteins

IDBP-28141

integrin, alpha M (complement component 3 receptor 3 subunit)

IDBP-588493

integrin, alpha M (complement component 3 receptor 3 subunit)

IDBP-745522

IDBP-751888

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20639876

ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 20639876

[Mus musculus] Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.

PMID 24423728

[Mus musculus] Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.

PMID 25538234

[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.

Entrez Gene

Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:31259990-31332892

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000287497	ENSP00000287497
ENST00000544665	ENSP00000441691
ENST00000570242
ENST00000567031	ENSP00000454568
ENST00000565142	ENSP00000461850
ENST00000561838
ENST00000569746
ENST00000567178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	21 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0014005	microglia development
GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0034142	toll-like receptor 4 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0050798	activated T cell proliferation
GO:0050900	leukocyte migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000030786

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000047238

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_6802

Innate Immune System pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_6900

Immune System pathway

REACT_6894

Toll Like Receptor 4 (TLR4) Cascade pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

hsa04145

Phagosome pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04640

Hematopoietic cell lineage pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04810

Regulation of actin cytoskeleton pathway

hsa05140

Leishmaniasis pathway

hsa05146

Amoebiasis pathway

hsa05150

Staphylococcus aureus infection pathway

INOH

INOH website

Integrin signaling pathway pathway

PID BIOCARTA

PID NCI

integrin_cs_pathway

Integrin family cell surface interactions

integrin2_pathway

Beta2 integrin cell surface interactions

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

P11215

TrEMBL

B3KXM6

UniProt Splice Variant

Entrez Gene

3684

UniGene

Hs.172631

RefSeq

NM_001145808 NM_000632 XM_006721045

HUGO

HGNC:6149

OMIM

120980

CCDS

CCDS54004 CCDS45470

HPRD

00411

IMGT

EMBL

AK127637 BC096346 BC096347 BC096348 BC099660 J03925 J04145 M18044 M76724 M84477 S52152 S52153 S52154 S52155 S52157 S52159 S52161 S52164 S52165 S52167 S52169 S52170 S52173 S52174 S52180 S52181 S52184 S52189 S52191 S52192 S52203 S52212 S52213 S52216 S52219 S52220 S52221 S52222 S52226 S52227

GenPept

AAA51960 AAA58410 AAA59491 AAA59544 AAA59903 AAB24821 AAH96346 AAH96347 AAH96348 AAH99660 BAG54538

RNA Seq Atlas

3684