Homo sapiens Gene: ITGAM
Summary
InnateDB Gene IDBG-28139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGAM
Gene Name integrin, alpha M (complement component 3 receptor 3 subunit)
Synonyms CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6;
Species Homo sapiens
Ensembl Gene ENSG00000169896
Encoded Proteins
integrin, alpha M (complement component 3 receptor 3 subunit)
integrin, alpha M (complement component 3 receptor 3 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
[Mus musculus] Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
Entrez Gene
Summary This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31259990-31332892
Strand Forward strand
Band p11.2
Transcripts
ENST00000287497 ENSP00000287497
ENST00000544665 ENSP00000441691
ENST00000570242
ENST00000567031 ENSP00000454568
ENST00000565142 ENSP00000461850
ENST00000561838
ENST00000569746
ENST00000567178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 21 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001846 opsonin binding
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002523 leukocyte migration involved in inflammatory response
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0014005 microglia development
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0034142 toll-like receptor 4 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045123 cellular extravasation
GO:0050798 activated T cell proliferation
GO:0050900 leukocyte migration
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Integrin cell surface interactions pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
amb2 Integrin signaling
Cross-References
SwissProt P11215
TrEMBL B3KXM6
UniProt Splice Variant
Entrez Gene 3684
UniGene Hs.172631
RefSeq NM_001145808 NM_000632 XM_006721045
HUGO HGNC:6149
OMIM 120980
CCDS CCDS54004 CCDS45470
HPRD 00411
IMGT
EMBL AK127637 BC096346 BC096347 BC096348 BC099660 J03925 J04145 M18044 M76724 M84477 S52152 S52153 S52154 S52155 S52157 S52159 S52161 S52164 S52165 S52167 S52169 S52170 S52173 S52174 S52180 S52181 S52184 S52189 S52191 S52192 S52203 S52212 S52213 S52216 S52219 S52220 S52221 S52222 S52226 S52227
GenPept AAA51960 AAA58410 AAA59491 AAA59544 AAA59903 AAB24821 AAH96346 AAH96347 AAH96348 AAH99660 BAG54538
RNA Seq Atlas 3684