Homo sapiens Gene: ITGAM | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-28139.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | ITGAM | ||||||||||||||||||||||||||||||
Gene Name | integrin, alpha M (complement component 3 receptor 3 subunit) | ||||||||||||||||||||||||||||||
Synonyms | CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; | ||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000169896 | ||||||||||||||||||||||||||||||
Encoded Proteins |
integrin, alpha M (complement component 3 receptor 3 subunit)
integrin, alpha M (complement component 3 receptor 3 subunit)
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||
Summary |
ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.
[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
[Mus musculus] Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
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Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 16:31259990-31332892 | ||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||
Band | p11.2 | ||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
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Pathways | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME |
Extracellular matrix organization pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Integrin cell surface interactions pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
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KEGG |
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Leishmaniasis pathway
Amoebiasis pathway
Staphylococcus aureus infection pathway
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INOH |
Integrin signaling pathway pathway
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PID BIOCARTA | |||||||||||||||||||||||||||||||
PID NCI |
Integrin family cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
amb2 Integrin signaling
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Cross-References | |||||||||||||||||||||||||||||||
SwissProt | P11215 | ||||||||||||||||||||||||||||||
TrEMBL | B3KXM6 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 3684 | ||||||||||||||||||||||||||||||
UniGene | Hs.172631 | ||||||||||||||||||||||||||||||
RefSeq | NM_001145808 NM_000632 XM_006721045 | ||||||||||||||||||||||||||||||
HUGO | HGNC:6149 | ||||||||||||||||||||||||||||||
OMIM | 120980 | ||||||||||||||||||||||||||||||
CCDS | CCDS54004 CCDS45470 | ||||||||||||||||||||||||||||||
HPRD | 00411 | ||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | AK127637 BC096346 BC096347 BC096348 BC099660 J03925 J04145 M18044 M76724 M84477 S52152 S52153 S52154 S52155 S52157 S52159 S52161 S52164 S52165 S52167 S52169 S52170 S52173 S52174 S52180 S52181 S52184 S52189 S52191 S52192 S52203 S52212 S52213 S52216 S52219 S52220 S52221 S52222 S52226 S52227 | ||||||||||||||||||||||||||||||
GenPept | AAA51960 AAA58410 AAA59491 AAA59544 AAA59903 AAB24821 AAH96346 AAH96347 AAH96348 AAH99660 BAG54538 | ||||||||||||||||||||||||||||||
RNA Seq Atlas | 3684 | ||||||||||||||||||||||||||||||