InnateDB Protein
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IDBP-28170.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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QTRT1
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Protein Name
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queuine tRNA-ribosyltransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000250237
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InnateDB Gene
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IDBG-243406 (QTRT1)
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Protein Structure
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Function |
Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Weakly associates with mitochondria, possibly via QTRTD1. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002616
tRNA-guanine(15) transglycosylase-like
IPR004803
Queuine tRNA-ribosyltransferase
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PFAM |
PF01702
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXR0
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PhosphoSite |
PhosphoSite-Q9BXR0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
81890
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UniGene |
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RefSeq |
NP_112486
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HUGO |
HGNC:23797
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OMIM |
609615
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CCDS |
CCDS12248
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HPRD |
17943
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IMGT |
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EMBL |
AC011475
AF302783
AF302784
BC015350
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GenPept |
AAG60033
AAG60034
AAH15350
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