Version 5.4
Homo sapiens Gene: QTRT1
Summary
InnateDB Gene IDBG-243406.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QTRT1
Gene Name queuine tRNA-ribosyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213339
Encoded Proteins
IDBP-28170
queuine tRNA-ribosyltransferase 1
IDBP-371467
queuine tRNA-ribosyltransferase 1
IDBP-762344
IDBP-764298
IDBP-762928
IDBP-765038
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10701430-10713437
Strand Forward strand
Band p13.2
Transcripts
ENST00000250237 ENSP00000250237
ENST00000421333 ENSP00000389126
ENST00000587861
ENST00000592254 ENSP00000468811
ENST00000592376 ENSP00000465974
ENST00000591643 ENSP00000467394
ENST00000585885
ENST00000592531
ENST00000587500
ENST00000590705
ENST00000587599 ENSP00000464990
ENST00000589488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008479 queuine tRNA-ribosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0008616 queuosine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002825
View Gene Order
ENSBTAG00000037941
Not yet available
Cross-References
SwissProt
TrEMBL K7EL95
UniProt Splice Variant
Entrez Gene 81890
UniGene
RefSeq NM_031209
HUGO HGNC:23797
OMIM 609615
CCDS CCDS12248
HPRD 17943
IMGT
EMBL AC011475
GenPept
RNA Seq Atlas 81890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca