InnateDB Protein
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IDBP-28249.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP24
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Protein Name
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Rho GTPase activating protein 24
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264343
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InnateDB Gene
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IDBG-28243 (ARHGAP24)
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Protein Structure
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Function |
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269PubMed:15302923, ECO:0000269PubMed:15611138, ECO:0000269PubMed:16862148}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269PubMed:15302923, ECO:0000269PubMed:15611138, ECO:0000269PubMed:16862148}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N264
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PhosphoSite |
PhosphoSite-Q8N264
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83478
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UniGene |
Hs.672231
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RefSeq |
NP_112595
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HUGO |
HGNC:25361
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OMIM |
610586
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CCDS |
CCDS3611
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HPRD |
09804
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IMGT |
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EMBL |
AK091196
AK130576
AL136646
AY211925
BC047918
BC098580
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GenPept |
AAH47918
AAH98580
AAO65178
BAC03606
BAC85384
CAB66581
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