InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENC1

Summary

InnateDB Protein

IDBP-28389.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENC1

Protein Name

ectodermal-neural cortex 1 (with BTB-like domain)

Synonyms

CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10;

Species

Homo sapiens

Ensembl Protein

ENSP00000306356

InnateDB Gene

IDBG-28385 (ENC1)

Protein Structure

UniProt Annotation

Function

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism. {ECO:0000269PubMed:19424503}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:19424503}. Cytoplasm {ECO:0000269PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:19424503}.

Disease Associations

Tissue Specificity

Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down- regulated in neuroblastoma tumors.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0016567	protein ubiquitination
GO:0017148	negative regulation of translation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016363	nuclear matrix
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt