Homo sapiens Gene: ENC1
Summary
InnateDB Gene IDBG-28385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENC1
Gene Name ectodermal-neural cortex 1 (with BTB-like domain)
Synonyms CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10;
Species Homo sapiens
Ensembl Gene ENSG00000171617
Encoded Proteins
ectodermal-neural cortex 1 (with BTB-like domain)
ectodermal-neural cortex 1 (with BTB-like domain)
ectodermal-neural cortex 1 (with BTB-like domain)
ectodermal-neural cortex 1 (with BTB-like domain)
ectodermal-neural cortex 1 (with BTB-like domain)
ectodermal-neural cortex 1 (with BTB domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:74627406-74641424
Strand Reverse strand
Band q13.3
Transcripts
ENST00000302351 ENSP00000306356
ENST00000510316 ENSP00000423804
ENST00000509284
ENST00000508331 ENSP00000422943
ENST00000509127 ENSP00000426889
ENST00000537006 ENSP00000446289
ENST00000618628 ENSP00000479101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010976 positive regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0017148 negative regulation of translation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016363 nuclear matrix
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8507
UniGene Hs.686685
RefSeq NM_003633 NM_001256575 NM_001256576 NM_001256574
HUGO HGNC:3345
OMIM 605173
CCDS CCDS4021 CCDS58958
HPRD 05529
IMGT
EMBL
GenPept
RNA Seq Atlas 8507