Homo sapiens Protein: HSD17B11 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-28972.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | HSD17B11 | ||||||||||||||||||
Protein Name | hydroxysteroid (17-beta) dehydrogenase 11 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000351035 | ||||||||||||||||||
InnateDB Gene | IDBG-28970 (HSD17B11) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. | ||||||||||||||||||
Subcellular Localization | Secreted {ECO:0000305}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. {ECO:0000269PubMed:10800688, ECO:0000269PubMed:11165019, ECO:0000269PubMed:12697717, ECO:0000269PubMed:9888557}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR IPR002347 Glucose/ribitol dehydrogenase IPR013968 Polyketide synthase, KR |
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PFAM |
PF00106
PF08659 |
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PRINTS |
PR00080
PR00081 |
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PIRSF |
PIRSF000126
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SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q8NBQ5 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q8NBQ5 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 51170 | ||||||||||||||||||
UniGene | Hs.594923 | ||||||||||||||||||
RefSeq | NP_057329 | ||||||||||||||||||
HUGO | HGNC:22960 | ||||||||||||||||||
OMIM | 612831 | ||||||||||||||||||
CCDS | CCDS3619 | ||||||||||||||||||
HPRD | 10881 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC108516 AF126780 AF273056 AK075348 AY358553 BC008650 BC014327 BC016367 BC021673 BC036001 | ||||||||||||||||||
GenPept | AAF06939 AAH08650 AAH14327 AAH16367 AAH21673 AAH36001 AAM44459 AAQ88917 BAC11560 | ||||||||||||||||||