InnateDB Protein
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IDBP-29189.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CPSF4
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Protein Name
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cleavage and polyadenylation specific factor 4, 30kDa
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Synonyms
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CPSF30; NAR; NEB1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000292476
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InnateDB Gene
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IDBG-29187 (CPSF4)
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Protein Structure
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Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269PubMed:14749727, ECO:0000269PubMed:9224719}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000571
Zinc finger, CCCH-type
IPR001878
Zinc finger, CCHC-type
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PFAM |
PF00642
PF00098
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PRINTS |
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PIRSF |
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SMART |
SM00356
SM00343
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TIGRFAMs |
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Modification |
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SwissProt |
O95639
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PhosphoSite |
PhosphoSite-O95639
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TrEMBL |
C9K0K2
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UniProt Splice Variant |
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Entrez Gene |
10898
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UniGene |
Hs.489287
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RefSeq |
NP_006684
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HUGO |
HGNC:2327
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OMIM |
603052
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CCDS |
CCDS5664
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HPRD |
04338
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IMGT |
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EMBL |
AC073063
BC003101
BC050738
CH236956
CH471091
CR542161
EF191081
U79569
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GenPept |
AAD00321
AAH03101
AAH50738
ABN05292
CAG46958
EAL23878
EAW76667
EAW76668
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