Homo sapiens Gene: CPSF4
Summary
InnateDB Gene IDBG-29187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF4
Gene Name cleavage and polyadenylation specific factor 4, 30kDa
Synonyms CPSF30; NAR; NEB1;
Species Homo sapiens
Ensembl Gene ENSG00000160917
Encoded Proteins
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
cleavage and polyadenylation specific factor 4, 30kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3\' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3\' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99438922-99457371
Strand Forward strand
Band q22.1
Transcripts
ENST00000292476 ENSP00000292476
ENST00000436336 ENSP00000395311
ENST00000451876 ENSP00000396060
ENST00000430038 ENSP00000401496
ENST00000441580 ENSP00000402224
ENST00000412686 ENSP00000401150
ENST00000452047 ENSP00000392584
ENST00000440514 ENSP00000415188
ENST00000484112
ENST00000471455
ENST00000465132
ENST00000469897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0019048 modulation by virus of host morphology or physiology
GO:0019054 modulation by virus of host process
GO:0019058 viral life cycle
GO:0046778 modification by virus of host mRNA processing
Cellular Component
GO:0005654 nucleoplasm
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Influenza Infection pathway
Inhibition of Host mRNA Processing and RNA Silencing pathway
NS1 Mediated Effects on Host Pathways pathway
Host Interactions with Influenza Factors pathway
Disease pathway
KEGG
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
Polyadenylation of mrna [Biocarta view]
PID NCI
Cross-References
SwissProt O95639
TrEMBL B7Z7B0 C9JEV9 C9K0K2 F8WEL7 H7C016
UniProt Splice Variant
Entrez Gene 10898
UniGene Hs.489287
RefSeq NM_001081559 NM_006693
HUGO HGNC:2327
OMIM 603052
CCDS CCDS47652 CCDS5664
HPRD
IMGT
EMBL AC073063 AK301745 BC003101 BC050738 CH236956 CH471091 CR542161 EF191081 U79569
GenPept AAD00321 AAH03101 AAH50738 ABN05292 BAH13546 CAG46958 EAL23878 EAW76667 EAW76668
RNA Seq Atlas 10898