InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMP1

Summary

InnateDB Protein

IDBP-29192.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMP1

Protein Name

dentin matrix acidic phosphoprotein 1

Synonyms

ARHP; ARHR; DMP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000340935

InnateDB Gene

IDBG-29190 (DMP1)

Protein Structure

UniProt Annotation

Function

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. {ECO:0000269PubMed:12615915}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12615915}. Cytoplasm {ECO:0000269PubMed:12615915}. Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:12615915}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.

Disease Associations

Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1) [MIM:241520]: A hereditary form of hypophosphatemic rickets, a disorder of proximal renal tubule function that causes phosphate loss, hypophosphatemia and skeletal deformities, including rickets and osteomalacia unresponsive to vitamin D. Symptoms are bone pain, fractures and growth abnormalities. {ECO:0000269PubMed:17033621, ECO:0000269PubMed:17033625}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization
GO:0031214	biomineral tissue development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle