Version 5.4
| Homo sapiens Gene: DMP1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-29190.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | DMP1 | ||||||||||||||||||
| Gene Name | dentin matrix acidic phosphoprotein 1 | ||||||||||||||||||
| Synonyms | ARHP; ARHR; DMP-1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000152592 | ||||||||||||||||||
| Encoded Proteins |
dentin matrix acidic phosphoprotein 1
dentin matrix acidic phosphoprotein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:87650307-87664361 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q22.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Extracellular matrix organization pathway
ECM proteoglycans pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
AP-1 transcription factor network
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| Cross-References | |||||||||||||||||||
| SwissProt | Q13316 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 1758 | ||||||||||||||||||
| UniGene | Hs.652366 | ||||||||||||||||||
| RefSeq | NM_001079911 NM_004407 | ||||||||||||||||||
| HUGO | HGNC:2932 | ||||||||||||||||||
| OMIM | 600980 | ||||||||||||||||||
| CCDS | CCDS3623 CCDS43249 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | BC130581 BC132865 CH471057 U34037 U65378 U89012 | ||||||||||||||||||
| GenPept | AAA97602 AAB87728 AAC51332 AAI30582 AAI32866 EAX05996 | ||||||||||||||||||
| RNA Seq Atlas | 1758 | ||||||||||||||||||