Version 5.4
Homo sapiens Protein: ATG4B
Summary
InnateDB Protein IDBP-292372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4B
Protein Name ATG4 autophagy related 4 homolog B (S. cerevisiae)
Synonyms APG4B; AUTL1;
Species Homo sapiens
Ensembl Protein ENSP00000384661
InnateDB Gene IDBG-85252 (ATG4B)
Protein Structure
UniProt Annotation
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269PubMed:15169837, ECO:0000269PubMed:15187094, ECO:0000269PubMed:17347651, ECO:0000269PubMed:19322194, ECO:0000269PubMed:21177865, ECO:0000269PubMed:22302004}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. {ECO:0000269PubMed:12446702, ECO:0000269PubMed:15169837}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005078 Peptidase C54
PFAM PF03416
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4P1
PhosphoSite PhosphoSite-Q9Y4P1
TrEMBL C9JVD5
UniProt Splice Variant
Entrez Gene 23192
UniGene Hs.283610
RefSeq XP_005247052
HUGO HGNC:20790
OMIM 611338
CCDS
HPRD 16499
IMGT
EMBL AB023160 AB066215 AC133528 AJ504652 AK027332 AK027462 AK027763 AK125277 AL080168 BC000719
GenPept AAH00719 AAY14919 BAA76787 BAB55042 BAB55127 BAB55353 BAB83890 BAC86110 CAB45756 CAD43219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca