InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAD1L1

Summary

InnateDB Protein

IDBP-292492.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAD1L1

Protein Name

MAD1 mitotic arrest deficient-like 1 (yeast)

Synonyms

MAD1; PIG9; TP53I9; TXBP181;

Species

Homo sapiens

Ensembl Protein

ENSP00000385334

InnateDB Gene

IDBG-6719 (MAD1L1)

Protein Structure

UniProt Annotation

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. {ECO:0000269PubMed:10049595, ECO:0000269PubMed:12837246, ECO:0000269PubMed:20133940}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.

Disease Associations

Note=Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Tissue Specificity

Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000089	mitotic metaphase
GO:0000090	mitotic anaphase
GO:0000093	mitotic telophase
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0090235	regulation of metaphase plate congression

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0072686	mitotic spindle